Uncle Mo has thrown a shoe into the mix of early wagering for the Kentucky Derby.

The 2-year-old champion of 2010 and impressive winner of the Breeders Cup Juvenile at Churchill Downs last November, is being treated for a gastrointestinal infection, on the heels of his upset on April 9, in the G1 Wood Memorial at Aqueduct.

It was his first defeat in five career starts, and according to owner, Mike Repole, if Uncle Mo is not “one hundred percent” in time for the Kentucky Derby, he will skip the race and be pointed for the Preakness, instead.

In the meantime, trainer Todd Pletcher, winner of last year’s Derby with Super Saver, has scheduled Uncle Mo for a workout at Churchill on Tuesday, April 26.

“His appetite is the best its been since the Wood and we’re really, really pleased with the progress we’re making at the moment,” Pletcher told the Times Union of Albany, NY. “We haven’t had to adjust his training much at all.”

Uncle Mo, sired by Indian Charlie, won the one-mile Timely Writer Stakes at Gulfstream Park on March 12, in his 3-year-old debut. It was his only other start this year.

Recent 2-year-old champions to come back at three and win the Kentucky Derby include Canadian champion Mine That Bird in 2009 and Street Sense in 2007.

With or without Uncle Mo, Florida Derby winner Dialed In will be a Derby favorite off of his come-from-behind win on April 3 at Gulfstream.

Two of the last five Kentucky Derby winners also won the Florida Derby as their final prep for the Run for the Roses: Big Brown in 2008 and Barbaro in 2006.

Nick Zito, Dialed In’s trainer, won the 2010 Florida Derby with Ice Box, who was runnerup to Super Saver in last year’s Kentucky Derby.

Dialed In’s only loss in four starts came when he finished second against older horses in a Gulfstream allowance in March. But the Mineshaft son won his only start at two, at Churchill Downs, despite a slow start in a 12-horse field, and he nailed his 3-year-old debut going away in the G3 Holy Bull at Gulfstream.

Hall of Fame trainer Zito, who won the Kentucky Derby with Go For Gin in 1994 and Strike The Gold in 1991, conditions Dialed in for Robert LaPenta, the owner of 2010 runnerup Ice Box.

Thanks to his win over Uncle Mo in the Wood Memorial, Toby’s Corner, with a 4-win record from 6 starts, also ranks among early Derby favorites.

Trained by Graham Motion, Toby’s Corner won his first two races this year, including the Whirlaway Stakes at Aqueduct, before he disappointed backers with a third-place finish in the G3 Gotham on March 11.

Toby’s Corner is owned by his breeder, Dianne Cotter, who also bred his sire, Bellamy Road, the beaten favorite in the 2005 Kentucky Derby, after equaling the track record to win the Wood Memorial.

Toby’s Corner is named after a pony that Cotter and her husband kept for their granddaughter.

The 137th running of the Kentucky Derby will be telecast live from Churchill Downs on Saturday, May 7.